Interleukin-1 beta-induced anorexia is reversed by ghrelin

GONZALEZ P; CRAGNOLINI AB; SCIMONELLI T

Elsevier

Año: 2006 p. 3220 - 3220

p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: 200%;">Abstract  Interleukins, in particular interleukin-1b (IL-1b), reduce food intake after peripheral and central administration, which suggests that they contribute to anorexia during various infectious, neoplastic and autoimmune diseases. On the other hand, ghrelin stimulates food intake by acting on the central nervous system (CNS) and is considered an important regulator of food intake in both rodents and humans. In the present study, we investi