alpha-Melanocyte-stimulating hormone modulates lipopolysaccharide plus interferon-gamma-induced tumor necrosis factor-alpha expression but not tumor necrosis factor-alpha receptor expression in cultured hypothalamic neurons.

CARUSO C, ; SANCHEZ M; DURAND D; DE LA CRUZ PEREZ M; GONZALEZ P; LASAGA M; SCIMONELLI T

ELSEVIER SCIENCE BV

Año: 2010 vol. 227 p. 52 - 52

p style="margin: 0cm 0cm 0pt; line-height: 150%;" class="MsoNormal">In a previous work we showed that the melanocortin alpha-melanocyte stimulating hormone (a-MSH) exerts anti-inflammatory action through melanocortin receptor 4 (MC4R) in rat hypothalamus. In this work, we examined the effect of a-MSH on the expression of tumour necrosis factor-a (TNF-a) and interleu