Evidence that the effect of melanocortins on female sexual behavior in preoptic area is mediated by MC3 receptor. Participation of nitric oxide.·

NOCETTO C; CRAGNOLINI AB; SCHIÖTH H; SCIMONELLI TN

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Año: 2004 p. 537 - 537

p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: 150%;">Alpha-MSH is involved in reproductive processes and can regulate the expression of lordosis, an important component of female reproductive behavior in rats and many other species. In this study we investigated the effects of MSH peptides on lordosis behavior when injected in medial preoptic area (POA) of ovariectomised rats primed with estradiol. The results show an increase in lordotic activity after bilateral administration of a-MSH and g-MSH. Interestingly, the treatment with the MC4 receptor antagonist HS014 did not block the stimulatory effect of a