Artículos
Título:
ADRENOCORTICOTROPIC HORMONE INFLUENCES THE
Autor/es:
M. VOLOSLN, L. M. CANCELA, C. LAINO, M. MASSEX AND V. A. MOLINA
Editorial:
PERGAMON-ELSEVIER SCIENCE LTD
Referencias:
Año: 1991 vol. 30 p. 719 - 719
Resumen:
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Sammary--The influence of adrenocorticotropic hormone (ACTH) in the adaptive changes on central
dopaminc (DA) autoreceptors following chronic administration of desipramine (DMI) has been examined
in rats. Dopamine had an inhibitory effect on basal and K+-induced release of [3H]DA from slices of
striatum and n. accumbens of rats treated chronically (10 days) with ACTH (50 IU/kg, s.c.), DMI
(10 mg/kg, i.p.) or the combination of ACTH and DMI. In slices of n. accumbens, but not in slices of
striatum of rats exposed to the combined treatment of ACTH and DMI, a significant decrease in the
inhibitory effect of exogenous DA on stimulated release of [3H]DA was observed. Chronic administration
of ACTH or DMI alone had no effect. The effect of the combined tr