Opioid Influence on Some Aspects of Stereotyped Behavior Induced by Repeated Amphetamine Treatment

L. M. CANCELA, J. ARTINIAN AND S. FULGINITI

PERGAMON-ELSEVIER SCIENCE LTD

Año: 1988 vol. 30 p. 899 - 899

font face="Times New Roman" size="1"> CANCELA, L. M., J. ART1NL/~N AND S. FULGINITI. Opioid influence on some aspects of stereotyped behavior induced by repeated amphetamine treatment. PHARMACOL BIOCHEM BEHAV 30(4) 899-904, 1988.--Rats were administered repeated IP injections of dl-amphetamine (AMPH) according to a chronic escalating dose schedule (three doses per 24 hr, for four days, two days or one day). Animals treated for four days exhibited a diminished oral stereotypy in response to a challenge of 12 mg/kg AMPH or 2 mg/kg SC apomorphine (APO), 72 hr after withdrawal. Pretreatment with 2 mg/kg IP naloxone (NAL) during the period of chronic AMPH administration prevented the redu