A dopamine mechanism is implied in the acquisition and expression of amphetamine and stress-induced effects observed in the lymphocyte subpopulations.

MARÍA AMPARO ASSIS A, ALEJANDRA MARÍA PACCHIONI A,1, CÉSAR COLLINO B,C, MARÍA CONSTANZA PAZ CLAUDIA SOTOMAYOR B, ANA MARÍA BASSO A,2, LILIANA MARINA CANCELA

ELSEVIER SCIENCE BV

Año: 2008 vol. 584 p. 405 - 405

font face="AdvTT6120e2aa" size="1"> Drugs of abuse and stress are associated with changes in circulating cell populations and reductions in cell-mediated immune responses. Themain goal of this study was to determine the influence of repeated and acute D-amphetamine treatments on the foot-shock stress-induced effects on  the peripheral lymphocyte subpopulations, and the involvement of a dopamine mechanism in the development and expression of this phenomenon. Wistar rats received an acute (5 mg/kg/day i.p.) or a repeated (2 mg/kg/day i.p. during 9 days) amphetamine treatment, and were exposed to a foot-shock stress (1 mA, 3 s) 4 days after the last amphetamine injection. Another group was administered with haloperidol (1 mg/kg/day i.p.) 15 min previous to each daily amphetam