Developmental lead exposure induces opposite effects on ethanol intake and locomotion in response to central vs. Systemic cyanamide administration

MATTALLONI, M.S; DEZA-PONZIO, R; ALBRECHT, P.A; CANCELA, L.M; VIRGOLINI, M.B

ALCOHOL

ELSEVIER SCIENCE INC

Lugar: Amsterdam; Año: 2017

0741-8329

evelopmental lead exposure induces opposite effects on ethanolintake and locomotion in response to central vs. systemic cyanamideadministrationMara Soledad Mattalloni a, b, Romina Deza-Ponzio a, b, Paula Alejandra Albrecht a, b,Liliana Marina Cancela a, b, Miriam Beatriz Virgolini a, b, *a IFEC - CONICET, Haya de la Torre y Medina Allende, Ciudad Universitaria, 5016, Cordoba, Argentinab Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Cordoba, Haya de la Torre y Medina Allende, CiudadUniversitaria, 5016, Cordoba, ArgentinaLead (Pb) is a developmental neurotoxicant that elicits differential responses to drugs of abuse. Particularly,ethanol consumption has been demonstrated to be increased as a consequence of environmentalPb exposure, with catalase (CAT) and brain acetaldehyde (ACD, the first metabolite of ethanol) playing arole. The present study sought to interfere with ethanol