Modulation of Ethanol-Metabolizing Enzymes by Developmental Lead Exposure: Effects in Voluntary Ethanol Consumption

MIRIAM B. VIRGOLINI; MARA S. MATTALLONI; PAULA A. ALBRECHT; ROMINA DEZA-PONZIO ; LILIANA M. CANCELA

Frontiers in Behavioral Neuroscience

Frontiers in Behavioral Neuroscience

Año: 2017

1662-5153

br />Modulation of Ethanol-Metabolizing Enzymes by Developmental Lead Exposure: Effects in Voluntary Ethanol ConsumptionMiriam B. Virgolini* , Mara S. Mattalloni , Paula A. Albrecht , Romina Deza-Ponzioand Liliana M. CancelaIFEC-CONICET, Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba,Córdoba, ArgentinaThis review article provides evidence of the impact of the environmental contaminantlead (Pb) on the pattern of the motivational effects of ethanol (EtOH). To find amechanism that explains this interaction, the focus of this review article is on centralEtOH metabolism and the participating enzymes, as key factors in the modulation ofbrain acetaldehyde (ACD) accumulation and resulting effect on EtOH intake. Catalase(CAT) seems a good candidate for the shared mechanism between Pb and EtOH dueto both its antioxidant and its brain EtOH-metabolizing properties. CAT