CANCELA LILIANA MARINA
Congresos y reuniones científicas
Título:
Enkephalinergic system is involved in cocaine induced behavioral sensitization and the associated increase in brain derived neurotrophic factor in nucleus accumbens.
Autor/es:
AVALOS, M.P.; MONGI BRAGATO, B; ZAMPONI, E. ; ZIMMER A; MASCO, D. ; CANCELA, L.M.
Lugar:
Cordoba
Reunión:
Congreso; XIV Reunión Nacional - III Encuentro Internacional Asociación Argentina de Ciencias del Comportamiento; 2013
Resumen:
ENKEPHALINERGIC SYSTEM IS INVOLVED IN COCAINE INDUCED BEHAVIORAL
SENSITIZATION AND THE ASSOCIATED INCREASE IN BRAIN-DERIVED
NEUROTROPHIC FACTOR AND CREB ACTIVITY IN NUCLEUS ACCUMBENS
AVALOS, M.P. (1); MONGI BRAGATO, B. (1); ZAMPONI, E. (2); MASCÓ, D. (2); CANCELA, L. (1)
1) Instituto de Farmacología Experimental, FCQ, UNC.
2) Instituto de Investigaciones Biológicas y Tecnológicas , FCEFyN, UNC.
Repeated intermittent exposure to cocaine produces a progressively greater locomotor response to the drug (behavioral sensitization) which is generally coupled to a progressively greater drug-induced
increases in dopamine efflux in the nucleus accumbens (NAc). The process underlying behavioral sensitization involves a complex interplay between dopamine (DA) and others neurotransmitters and
neuropeptides such as glutamate, opioid peptides and brain-derived neurotrophic factor (BDNF). BDNF regulate drug-induced long-term neuroadaptations that encompass alterations in molecular
components at the synapse and changes in gene expression and is reported to alter glutamatergic and dopaminergic transmission in the brain areas associated with cocaine-induced sensitization. BDNF
protein and its receptor (TrkB) are induced in the Prefrontal cortex (PFC), NAc and Ventral Tegmental Area (VTA) after chronic cocaine treatment. On the other hand, opioid receptors and endogenous
opioid peptides, mainly enkephalin, are largely distributed in the mesocorticolimbic system. There is pharmacological evidence for a role of opioid receptors in the development and expression of
psychostimulant induced sensitization. However, enkephalin contribution to the induction and expression of this phenomenon on behavioral sensitization and associated molecular parameters has been
poorly studied. The main goal of this study was to demonstrate the involvement of the enkephalinergic system in cocaine-induced behavioral sensitization, and their association with changes in BDNF and
its receptor.
SENSITIZATION AND THE ASSOCIATED INCREASE IN BRAIN-DERIVED
NEUROTROPHIC FACTOR AND CREB ACTIVITY IN NUCLEUS ACCUMBENS
AVALOS, M.P. (1); MONGI BRAGATO, B. (1); ZAMPONI, E. (2); MASCÓ, D. (2); CANCELA, L. (1)
1) Instituto de Farmacología Experimental, FCQ, UNC.
2) Instituto de Investigaciones Biológicas y Tecnológicas , FCEFyN, UNC.
Repeated intermittent exposure to cocaine produces a progressively greater locomotor response to the drug (behavioral sensitization) which is generally coupled to a progressively greater drug-induced
increases in dopamine efflux in the nucleus accumbens (NAc). The process underlying behavioral sensitization involves a complex interplay between dopamine (DA) and others neurotransmitters and
neuropeptides such as glutamate, opioid peptides and brain-derived neurotrophic factor (BDNF). BDNF regulate drug-induced long-term neuroadaptations that encompass alterations in molecular
components at the synapse and changes in gene expression and is reported to alter glutamatergic and dopaminergic transmission in the brain areas associated with cocaine-induced sensitization. BDNF
protein and its receptor (TrkB) are induced in the Prefrontal cortex (PFC), NAc and Ventral Tegmental Area (VTA) after chronic cocaine treatment. On the other hand, opioid receptors and endogenous
opioid peptides, mainly enkephalin, are largely distributed in the mesocorticolimbic system. There is pharmacological evidence for a role of opioid receptors in the development and expression of
psychostimulant induced sensitization. However, enkephalin contribution to the induction and expression of this phenomenon on behavioral sensitization and associated molecular parameters has been
poorly studied. The main goal of this study was to demonstrate the involvement of the enkephalinergic system in cocaine-induced behavioral sensitization, and their association with changes in BDNF and
its receptor.
