Increased fear learning coincides with neural dysinhibition and facilitated LTP in the basolateral amygdala following benzodiazepine withdrawal in rats.

ISOARDI N.A., MARTIJENA I.D., CARRER H.F. AND V.A. MOLINA.

NEUROPSYCHOPHARMACOLOGY

Nature Publishing Group

Año: 2004 vol. 29 p. 1852 - 1852

0893-133X

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt">Animals chronically administered with diazepam (DZM -- 2 mg/kg/day i.p.) or vehicle (VEH) for 21 days were tested in a fear-conditioning paradigm 4 days after the last administration. Increased freezing was observed in DZM withdrawn rats as compared to VEH injected control rats in both associative and nonassociative context and this increase was greatest for the DZM withdrawal