INFLUENCE OF ETHANOL WITHDRAWAL ON FEAR MEMORY: EFFECT OF d-CYCLOSERINE

BERTOTTO ME, BUSTOS SG, MOLINA VA, MARTIJENA ID

Elsevier

Año: 2006 vol. 142 p. 979 - 979

h1 style="MARGIN: 0cm 0cm 0pt; LINE-HEIGHT: 200%; TEXT-ALIGN: center" align="center">Abstract  Animals made dependent via an ethanol-containing liquid diet (6% v/v) for 14 days were submitted to a contextual fear conditioning paradigm 3 days after the last consumption day. After conditioning, rats were subjected to 4 extinction trials by exposing the animals to the conditioned context and their freezing was evaluated for each trial. Immediately after the first extinction trial, all animals were either injected with saline or D-cycloserine 5 mg/kg i.p - a dose that did not influence the extinction in control rats -.