Gabaergic Modulation of The Stress Response

MARTIJENA I.D, RODRIGUEZ MANZANARES P, LACERRA C, MOLINA VA

WILEY-LISS, DIV JOHN WILEY & SONS INC

Año: 2002 p. 86 - 86

font face="NewCenturySchlbk-Roman" size="2"> the modulation of the central response to stress. In the present study we evaluate the influence of a brief restraint exposure on GABA-stimulated chloride influx in diverse brain areas presumed to have a major role in the mediation of emotional behaviors following aversive stimulation.Areduced chloride uptake after stress exposure was only observed in frontal cortex and amygdala. Moreover, rats subjected to such stressor performed an anxiogenic behavior when exposed later to the elevated plus-maze. A comparable behavior in the elevated plus-maze was observed between animals that were allowed to chew during the restraint experience and those without any stressful manipulation, suggesting that chewing served as an ef