A dopaminergic mechanism is involved in the ?anxiogenic-like? response induced by chronic amphetamine treatment: a behavioral and neurochemical study

CANCELA LM, BASSO AM, MARTIJENA ID, CAPRILES N, MOLINA VA

ELSEVIER SCIENCE BV

Año: 2001 p. 179 - 179

font face="Times New Roman" size="1"> The purpose of this study was to examine the influence of chronic d-amphetamine (AMPH) treatment (2 mg/kg i.p., for 9 consecutive days) on behavioral and neurochemical responses to a subsequent exposure ? 4 days after the last AMPH injection ? to the elevated plus-maze (EPM), as well as to determine the involvement of a dopaminergic mechanism in that influence. Results showed that chronic AMPH treatment induced an ?anxiogenic-like? response when animals were evaluated in the EPM test. Pretreatment with either haloperidol (HAL, 1 mg/kg i.p., 20 min prior to each injection) or SCH-23390 (0.1 mg/kg i.p., 10 min prior to each injection) completely