Stress-induced resistance to the fear memory labilization/reconsolidation process. Involvement of the basolateral amygdala complex

MARTIJENA IRENE DELIA

NEUROPHARMACOLOGY

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2016 vol. 109 p. 349 - 349

0028-3908

onsolidated memories can enter into a labile state after reactivation followedby a restabilization process defined as reconsolidation. This process can beinterfered with Midazolam (MDZ), a positive allosteric modulator of the GABA-Areceptor. The present study has evaluated the influence of prior stress on MDZ´s interfering effect. We also assessed the influence of both systemic andintra-basolateral amygdala (BLA) infusion of d-cycloserine (DCS), a partialagonist of the NMDA receptors, on the MDZ effect in previously stressed rats.Furthermore, we analyzed the effect of stress on the expression of Zif-268 andthe GluN2B sites, two molecular markers of the labilization/reconsolidationprocess, following reactivation. The results revealed that prior stress resulted into a memory trace that was insensitive to the MDZ impairing effect. Bothsystemic and intra-BLA DCS administration previous to reactivation restored MDZ´s disruptive effect on memory reconsolidation in stressed animals. Further,