Temporal dynamic of the hippocampal structural plasticity associated with the fear memory destabilization/reconsolidation process

MARTIJENA, IRENE DELIA

HIPPOCAMPUS

WILEY-LISS, DIV JOHN WILEY & SONS INC

Año: 2021 vol. 31 p. 1080 - 1080

1050-9631

econsolidation of a contextual fear memory is a protein synthesis dependent process in which a previously destabilized memory returns to a stable state. This process has become the subject of many studies due to its importance in memory processing, maintenance and updating; and its potential role as a therapeutical target in memory expression disorders such as phobias and post-traumatic stress disorder (PTSD). In this sense, understanding the underlying mechanisms of memory reconsolidation is paramount in developing potential treatments for such ailments. In the present work we studied the interaction between two key neural structures involved in the reconsolidation process: the basolateral complex of the amygdala (BLA) and the dorsal hippocampus (DH). Our results show changes in the structural plasticity of the CA1 region of the DH in the form of dendritic spines density changes associated with the destabilization/reconsolidation process. Furthermore, we demonstrate a modulatory role