Oncoproteins induce multilamellar structure formation in DMPC vesicles

tucuman

Congreso; XLI Reunión anual de la Sociedad Argentina de Biofísica; 2012

Sociedad Argentina de Biofísica

Interfacial properties of oncoproteins and their interaction with phospholipidsRESERVADO SABGraciela BorioliDepartamento de Química Biológica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. gborioli@mail.fcq.unc.edu.arOncoproteins induce cellular transformation under normal condition, and cancer when they are deregulated. Their best known function is to modulate transcription, so their most natural context for interactions is promoter DNA regions. DNA and other transcription factors are therefore widely viewed as their sole relevant partners. However, gathering evidence converges from biophysical and from molecular and cellular studies showing that some Immediate-Early oncoproteins, which are mobilized in the cell shortly after receiving a stimulus, have functions directly linked with membranes and exceeding strict DNA related interactions.Our viewpoint is that transcription factors with the features of Immediate Early oncoproteins accomplish their role in cellular processes not only through association to DNA related to transcription, but also through their association with membranes. Moreover, some of these proteins can sense the state and composition of the membrane and are able to transduce this information. We discuss molecular properties that determine interfacial behavior and interaction with phospholipids in membrane models, transduction capacity, and remodeling effects of oncoproteins.Agradecimientos: SECyT-UNC, FONCyT and CONICET. GB is a career investigator of CONICET. Dr. Bruno Maggio has contributed to this work with the initial spark and many valuable discussions.