In vivo immunomodulatory effects of aqueous extracts of Larrea divaricata Cav.

DAVICINO R, MATTAR A, CASALI Y, PORPORATTO C, CORREA SG, MICALIZZI B.

IMMUNOPHARMACOLOGY IMMUNOTOXICOLOGY

Francis & Taylor Group

Lugar: Immunopharmacol Immunotoxicol. ; Año: 2007 vol. 29 p. 351 - 351

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt">Several medicinal plants are considered immunomodulatory as they display a variety of anti-inflammatory, antimicrobial and antitumoral effects.  Larrea divaricata Cav. (jarilla) (Zygophyllaceaea) is a plant widely used in popular medicine to treat tumors, infections, and inflammatory diseases.  So far, the immunostimulating activities of Larrea divaricata have not been studied in vivo.  In this work, we used healthy mice to assess the immunomodulatory potential of aqueous extracts of Larrea divaricata Cav. We fund that Decoction (D) and Infusion (I) from Larrea divaricata cav showed any acute hepatotoxic activity. Only D at 0.5 mg/kg increased the carrageenan-induced inflammation. Macrophages harvested from treated mice showed no signs of apoptosis. These cells showed a significant increase in NO and TNF al