High dissemination and hepatotoxicity in animals infected with C.albicans: potencial sensitization to liver damage alter stress exposure

CORREA SG, RODRÍGUEZ-GALÁN MC, SALIDO-RENTERÍA B, CANO R, CEJAS H AND SOTOMAYOR CE

INTERNATIONAL IMMUNOLOGY

Oxford University Press

Año: 2004 vol. 16 p. 1761 - 1761

0953-8178

he liver constitutes the first barrier in the control of hematogenous dissemination for Candida albicans of intestinal origin. The ability of this organ to limit the growth of the yeast and to mount an efficient inflammatory reaction is crucial in determining the outcome of the fungal infection. When rats infected with C. albicans are exposed to chronic varied stress, the cell recruitment is impaired at the site of the infection, the tissue reaction is highly disorganized in target organs and the infection evolution is more severe. At hepatic level, higher fungal burden is associated with hyphal form and the consistent presence of steatosis (fatty liver). Herein we aimed at characterizing the steatosis associated with C. albicans infection and to provide molecular evidence of the correlation among liver injury markers, stress products and the initiation of the inflammatory tissue reaction. After 3 days of stress and infection, we observed micro and macro steatosis in acinar zone 1 (sp