Modulation of gut immune response by probiotic fermented milk consumption to control IgE in a respiratory allergy model

VELEZ, E.; NOVOTNY-NUÑEZ, I.; CORREA, S.; PERDIGÓN, G.; MALDONADO-GALDEANO, C.

Beneficial Microbes

Wageningen Academic Publishers

Año: 2021 p. 1 - 1

1876-2883

llergies are a world increasing health issue and most treatments are oriented to alleviate symptoms. Probiotics have several health benefits including the improvement of the immune system. In previous work we found that consumption of commercial probiotic fermented milk (PFM) significantly reduced specific-immunoglobulin (Ig) E in serum and lungs by increasing specific-IgG and controlled allergic response to ovalbumin (OVA) in an adult mouse respiratory allergy model. Here we continued our study determining the mechanism triggered in the gut by the PFM ingestion that influenced the results previously reported. Five groups of BALB/c mice were assessed: normal-control, basal (drinks PFM five days without OVA sensitisation), sensitisation-control (no PFM intake), previous and continuous-PFM administration. Allergen administration: 3 OVA injections (1% in PBS) followed by aerosols exposure for 7 days. We determined total secretory-IgA and cytokines in small intestine (SI) fluid; CD11b+, C