Artículos
Título:
Regulation of membrane expansion at the nerve growth cone
Autor/es:
K. H. PFENNINGER; L. LAURINO; D. PERETTI; L. LAURINO,; S. ROSSO; G. MORFINI; A. CÁCERES; S. QUIROGA
Revista:
JOURNAL OF CELL SCIENCE
Referencias:
Año: 2003 vol. 116 p. 1209 - 1209
Resumen:
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Exocytotic incorporation of plasmalemmal precursor
vesicles (PPVs) into the cell surface is necessary for neurite
extension and is known to occur mainly at the growth cone.
This report examines whether this is a regulated event
controlled by growth factors. The Golgi complex and
nascent PPVs of hippocampal neurons in culture were
pulse-labeled with fluorescent ceramide. We studied the
dynamics of labeled PPVs upon arrival at the axonal
growth cone. In controls and cultures stimulated with
brain-derived neurotrophic factor (BDNF), PPV clusters
persisted in growth cones with a half-life (t1/2