NMDA antagonist MK 801 in nucleus accumbens core but not shell disrupts the restraint stress-induced reinstatement of extinguished cocaine-conditioned place preference in rats

DE GIOVANNI L.M.; GUZMAN, A.S.; VIRGOLINI M.B.; CANCELA, L.M.

BEHAVIOURAL BRAIN RESEARCH

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2016 vol. 315 p. 150 - 150

0166-4328

Relapse is a common feature of cocaine addiction. In rodents, it can be elicited by cues, stress or the drug.Restraint stress-induced reinstatement of cocaine-conditioned place preference (CPP) is a useful modelto study the mechanisms involved in stress-induced relapse of drug-seeking behavior. There is evidencethat the glutamate NMDA receptors are critically involved in drug- and cue-induced reinstatement ofseeking behavior and drug-CPP responses. The aim of this study was to investigate the contribution ofNMDA receptors within core vs. shell nucleus accumbens (NAc) subregions to restraint stress-inducedreinstatement of extinguished cocaine-CPP. After extinction of cocaine-conditioned preference, animalswere administered MK 801 systemically or directly into intra-core or intra-shell, and restrained for 30 minor left undisturbed in their home-cages. First, we demonstrated that restraint stress-induced reinstatementof extingui