Environmental exposure to lead and oxidative stress biomarkers among healthy children in La Plata, Argentina Exposición ambiental a plomo y biomarcadores de estrés oxidativo en niños sanos de La Plata, Argentina

DISALVO, LILIANA; CASSAIN, VIRGINIA; FASANO, MARÍA V; ZAR, GAMALIEL; VAREA, ANA; VIRGOLINI, MIRIAM B.

ARCHIVOS ARGENTINOS DE PEDIATRIA

NLM (Medline)

Año: 2022 vol. 120 p. 174 - 174

0325-0075

NTRODUCTION: Environmental exposure to lead is still a major public health problem, especially in children. Oxidative stress may be a primary mechanism associated with toxicity. The objective of this study was to measure blood lead levels (BLLs) in children aged 1 to 6 years exposed to lead in La Plata and suburban areas and their relation to oxidative stress biomarkers. POPULATION AND METHODS: Cross-sectional, analytical study. Clinically healthy children aged 1 to 6 years were analyzed. BLLs, antioxidant enzyme activity, and extent of lipid peroxidation were measured. The statistical software package R, version 3.5.1, was used. RESULTS: A total of 131 children participated; their median age was 2.33 years. The geometric mean of BLLs was 1.90 μg/dL; 32% showed a measurable BLL and 3%, BLLs ≥ 5 μg/dL (international reference). The comparison of oxidative stress biomarkers based on BLLs showed a significant difference in median thiobarbituric acid reactive substances (T