Binge eating promotes ethanol self-administration in female rats with a history of intermittent ethanol exposure at adolescence

LEYVA, LEANDRO RUIZ; SALGUERO, AGUSTÍN; VIRGOLINI, MIRIAM BEATRIZ; ROMERO, VERÓNICA LEONOR; MARENGO, LEONARDO; FABIO, MARÍA CAROLINA; MORÓN, IGNACIO; CENDÁN, CRUZ MIGUEL; PAUTASSI, RICARDO MARCOS

DRUG AND ALCOHOL DEPENDENCE

ELSEVIER IRELAND LTD

Año: 2023 vol. 243

0376-8716

ackground: Ethanol drinking begins during adolescence and, particularly when occurs in a binge-like pattern, exerts lingering adverse consequences. Pre-clinical studies indicate that intermittent ethanol exposure (IEA, a model of repeated ethanol intoxication), or binge eating (BE) can increase subsequent ethanol consumption. It is unknown if the promoting effects of BE upon ethanol drinking are found in female rats and are modulated by IEA at adolescence. This study assessed interactive effects between IEA and BE, upon ethanol drinking. Methods: Female Wistar rats were given 4.0 g/kg ethanol, every other day from postnatal day 25–45. At adulthood, they were exposed to sessions in which a brief offering of a sizeable portion of highly palatable sugary pills was followed by a 120-min exposure to an ethanol bottle. Results: Exploratory activity and recognition memory was not affected by the IEA. Glutathione peroxidase and catalase activity, and lipid peroxidation (measured in blood and