The intertwining between lead and ethanol in the model organism Caenorhabditis elegans

ALBRECHT, P. A.; FERNANDEZ-HUBEID, L .E.; DEZA-PONZIO, R.; VIRGOLINI, M. B.

Frontiers in Toxicology

Frontiers

Año: 2022 vol. 4

aenorhabditis elegans (C. elegans) is a model organism widely used toevaluate the mechanistic aspects of toxicants with the potential to predictresponses comparable to those of mammals. We report here the consequencesof developmental lead (Pb) exposure on behavioral responses to ethanol (EtOH)in C. elegans. In addition, we present data on morphological alterations in thedopamine (DA) synapse and DA-dependent behaviors aimed to dissect theneurobiological mechanisms that underlie the relationship between theseneurotoxicants. Finally, the escalation to superior animals that parallels theobserved effects in both experimental models with references to EtOHmetabolism and oxidative stress is also discussed. Overall, the literaturerevised here underpins the usefulness of C. elegans to evidence behavioralresponses to a combination of neurotoxicants in mechanistic-orientatedstudies.