VIRGOLINI MIRIAM BEATRIZ
Congresos y reuniones científicas
Título:
Systemic vs. central cyanamide administration modulates the motivational and stimulant effects of ethanol in developmentally low-level lead exposed rats
Autor/es:
MATTALLONI, M.S.; DE GIOVANNI, L.N.; CANCELA, L.M.; VIRGOLINI, M.B.
Lugar:
Valdivia, Chile
Reunión:
Congreso; VI Neurotoxicity Society Meeting: Mechanisms of neurodegenerative disorders; 2013
Institución organizadora:
NeuroToxicity Society
Resumen:
Previous evidences demonstrate a higher reactivity to several effects of ethanol in developmentally low-level lead (Pb) exposed rats. This study aimed to evaluate the influence of cyanamide, a drug that modifies ethanol metabolism by inhibiting ALDH and to a lesser extent catalase, on the motivational and stimulant properties of ethanol. Thirty-five day-old male Wistar pups perinatally exposed to 220 ppm Pb were evaluated in their ethanol intake in a free-choice limited paradigm (2 h) at increasing ethanol concentrations (2-10%); immediately thereafter their ethanol-induced locomotor activity was assessed. Cyanamide was centrally and systemically administered in both tests. The results demonstrated that Pb-exposed rats voluntarily consumed more ethanol and showed ethanol-induced hyperlocomotion in relation to their respective controls, being both effects reversed by systemically-administered cyanamide. On the opposite, when cyanamide was administered centrally, only the control animals evidenced an increase in ethanol intake, although both groups showed an increase in ethanol-induced locomotor activity. The interplay between centrally-formed (reinforcing) and peripheral (aversive) acetaldehyde reveal the importance of ethanol metabolism in the higher motivational and stimulant effects observed in developmentally Pb-exposed rats.
