Differential role of CB1 receptors within accumbal subregions in stress-induced reinstatement of cocaine-conditioned preference

GUZMAN AS; DE GIOVANNI LN; VIRGOLINI MB; CANCELA LM

Congreso; IUSN-ESN MEETING; 2017

WTH08-07Differential role of CB1 receptors within accumbal subregions in stress-induced reinstatement of cocaine-conditioned preferenceA. Guzman, L. De Giovanni, M. Virgolini, L. CancelaInstituto de Farmacologia Experimental de Cordoba, Departamento de Farmacologia - FCQ - UNC, Cordoba, ArgentinaStress is considered one of the most important factors known to induce relapse in human addicts and in animal models of drug addiction. Research from our laboratory demonstrates that, using a conditioned place preference (CPP) paradigm, an acute restraint stress exposure triggers reinstatement of cocaine-CPP. With regard to the neurobiological mechanisms underlying relapse, there are numerous evidences for the participation of the endocannabinoid system (ECS), primarily through their actions at the widely distributed CB1 receptors (CB1R). Nevertheless, the role of ECS in stress-induced reinstatement has not been extensively studied. Considering that subregions of the Nucleus Accumbens (NAc) contribute significantly, but differently, to the impact of drug and stress on addiction, the present study has been designed to evaluate the involvement of CB1R within Core and Shell compartments of NAc in a restraint stress?induced reinstatement model. Male Wistar rats (220?300 g) that extinguished cocaine-CPP were