Angiotensin II AT1 receptor blockade selectively enhances brain AT2 receptor expression, and abolishes the cold restraint stress-induced increase in tyrosine hydroxylase mRNA in the locus coeruleus of spontaneous hypertensive rats

24. BREGONZIO, C.; SELTZER, A; ARMANDO, I. PAVEL, J.; SAAVEDRA, J.M

TAYLOR & FRANCIS LTD

Lugar: Amsterdam; Año: 2008 vol. 11 p. 457 - 457

p style="margin: 12pt 6pt 0pt 36pt;" class="abstract">Spontaneously hypertensive rats, a stress-sensitive strain, were pretreated orally for 14 days with the AT(1) receptor antagonist candesartan before submission to 2 h of cold-restraint stress. In non-treated rats, stress decreased AT(1) receptor binding in the median eminence and basolateral amygdala, increased AT(2) receptor binding in the medial subnucleus of the inferior olive, decreased AT(2) binding in the ventrolateral thalamic nucleus and increased tyrosine hydroxylase mRNA level in the locus coeruleus. In non-stressed rats, AT(1) receptor blockade reduced AT(1) receptor binding in all areas studied and enhanced AT(2) receptor binding in the medial subnucleus of the inferior olive. Candesartan pretreatment produced a similar decrease in brain AT(1) binding after stress, and prevented the stress-induced AT(2) receptor binding decrease in the ventrolateral thalamic