Brain Angiotensin II AT1 receptors are involved in the acute and long-term amphetamine-induced neurocognitive alterations

MARCHESE NA; ARTUR DE LA VILLARMOIS E; BASMADJIAN M; PEREZ MF; BAIARDI, G; BREGONZIO C

PSYCHOPHARMACOLOGY

SPRINGER

Lugar: Berlin; Año: 2016 p. 795 - 795

0033-3158

!--[if gte mso 9]> Rationale. AngiotensinII, by activation of its brain AT1-receptors, plays an active roleas neuromodulator in dopaminergic transmission. These receptors participate inthe development of Amphetamine-induced behavioral and dopamine releasesensitization. Dopamine is involved in cognitive processes and providesconnectivity between brain areas related to these processes. Amphetamine by itsmimetic activity over dopamine neurotransmission, elicits differentialresponses after acute administration or