Brain angiotensin II involvement in central nervous system chronic disorders

BASMADJIAN M; OCCHIEPO V; MARCHESE NA; BAIARDI, G; BREGONZIO C

PROTEIN AND PEPTIDE LETTERS

BENTHAM SCIENCE PUBL LTD

Lugar: Oak Park; Año: 2017

0929-8665

he functioning of the central nervous system is complex and it implies tight and coordinated interactions among multiple components. Neurotransmitters systems imbalance is a hallmark in central nervous system (CNS) disorders. These pathologies profoundly impact on social, cultural, and economic perspective worldwide. The etiopathology of CNS illnesses is still poorly understood making their treatment difficult. Brain angiotensin II (Ang II), through its AT1 receptors, modulates dopaminergic, glutamatergic and GABAergic neurotransmission, which are responsible for movement control, cognition, emotions and stress responses. Alterations of these functions, concomitant with modified brain renin-angiotensin system (RAS) components, have been described in CNS pathologies like depression, Parkinson, Alzheimer, and schizophrenia. In this sense, altered functionality of angiotensin I converting enzyme and AT1 receptors, is associated with augmented susceptibility to the occurrence of these pat