Brain angiotensin II in dopaminergic imbalance-derived pathologies: neuroinflammation and vascular responses

OCCHIEPPO, VICTORIA BELÉN; BASMADJIAN, OSVALDO MARTÍN; BREGONZIO, CLAUDIA

NEURAL REGENERATION RESEARCH

SHENYANG EDITORIAL DEPT NEURAL REGENERATION RES

Año: 2021

1673-5374

rain angiotensin II (ANG I I ) a s apleiotropic player: Mental disordershave been commonly associated withan imbalance in many neurotransmittersystems, such as dopamine, glutamate, andgamma-aminobutyric acid. Consideringthe complexity of brain functioning, allcomponents of the neurovascular unitshould be considered in studies for a bettercomprehension of the physiopathology andpossible therapeutics. ANG II is present inthe brain and binds to AT1 receptors (AT1-R),located in the neurovascular unit and hasa close relationship with the mentionedneurotransmitter systems. In pathologicalconditions, AT1-R expressed in astrocytes,microglia, and brain endothelial cells arekey mediators in the development of anoxidative/inflammatory microenvironment,as well as in glial activation. Therefore,pharmacological intervention targeting AT1-Rprovides a holistic and moderated approachto modulate neurotransmission systems inaddition to the glial and vascular responses(Figure 1). This interaction is unde