AT1-R is involved in the development of long-lasting, region-dependent and oxidative stress-independent astrocyte morphological alterations induced by Ketamine

BREGONZIO, CLAUDIA

EUROPEAN JOURNAL OF NEUROSCIENCE

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2020

0953-816X

strocytes play an essential role in the genesis, maturation and regulation of theneurovascular unit. Multiple evidence support that astrocyte reactivity has a closerelationship to neurovascular unit dysfunction, oxidative stress and inflammation,providing a suitable scenario for the development of mental disorders. Ketamine has beenproposed as a single-use antidepressant treatment in major depression and itsantidepressant effects have been associated with anti-inflammatory properties. However,Ketamine long-lasting effects over the neurovascular unit components remain unclear.Angiotensin II AT1 receptor (AT1-R) blockers have anti-inflammatory, antioxidant andneuroprotective effects. The present work aims to distinguish the acute and long-termKetamine effects over astrocytes response extended to other neurovascular unitcomponents, and the involvement of AT1-R, in prefrontal cortex and ventral tegmentalarea. Male Wistar rats were administered with AT1-R antagonist Candesartan/vehicle(day