Prenatal Amphetamine-Induced Dopaminergic Alteration in a Gender- and Estrogen-Dependent Manner

PENNACCHIO, G. E.; SANTONJA, F. E.; NEIRA, F. J.; BREGONZIO, C.; SOAJE, M.

NEUROCHEMICAL RESEARCH

SPRINGER/PLENUM PUBLISHERS

Año: 2022 vol. 47 p. 1317 - 1317

0364-3190

renatal exposure to amphetamine induces changes in dopamine receptors in mesolimbic areas and alters locomotor responseto amphetamine during adulthood. Sex diferences have been reported in amphetamine-induced brain activity and stresssensitivity. We evaluated the efects of prenatal amphetamine exposure on locomotor activity, dopamine receptors andtyrosine hydroxylase mRNA expression in nucleus accumbens and caudate-putamen in response to amphetamine challengein adult female and male rats. The role of estrogen in the response to restraint stress was analyzed in ovariectomized, prenatally amphetamine-exposed rats. Pregnant rats were treated with d-amphetamine during days 15?21 of gestation. Nucleusaccumbens and caudate-putamen were processed for mRNA determination by real-time PCR. In nucleus accumbens, highermRNA dopamine (D3) receptor expression was found in basal and d-amphetamine-challenge conditions in female than male,and prenatal amphetamine increased the diference. No sex difere