BREGONZIO DIAZ CLAUDIA
Capítulos de libros
Título:
Role of the Neuropeptide Angiotensin II in Stress and Related Disorders
Autor/es:
BREGONZIO C; MARINZALDA MA; BAIARDI, G; GARGIULO, PA
Libro:
Psychiatry and Neuroscience Update. Bridging the divide
Editorial:
Springer
Referencias:
Año: 2015; p. 79 - 88
Resumen:
Angiotensin II (Ang II) was described as a peripheral hormone;
its synthesis and metabolism were characterized and it is currently
known as the renin-angiotensin system (RAS). All the components
of the RAS, including the receptors, have been found in brain tissue,
indicating a role as a hormone or neuromodulator in the central nervous
system. Ang II exerts its principal known actions at the AT1 receptor.
Its functions related to AT2 receptors are controversial and associated
with AT1 opposite effects, although there is evidence showing crosstalk
between both receptors. The metabolism of Ang II generates
other active peptides, such as Angiotensin 1?7 and Angiotensin IV,
which will not be discussed. Neurobiological research has explained
many of the different neuroendocrine and behavioral responses to
stressors. Stress is a complex phenomenon in response to physical,
environmental, or psychological stimulus. Stress triggers important
adaptive functions improving health and survival. Meanwhile,
excessive stress can be deleterious, therefore, individuals unable to
cope with stress are highly vulnerable to a variety of diseases. Stress
is a major contributor of cardiovascular disorders and psychiatric
illness such as anxiety and depression. Many studies have confirmed
that stress also increases the vulnerability to drug abuse.
The role of Ang II at the periphery and in the central nervous system
is vast and complex. For this reason, in this chapter we will focus
on the role of brain RAS in stress responses and related pathologies
from many other important aspects of Ang II research.
its synthesis and metabolism were characterized and it is currently
known as the renin-angiotensin system (RAS). All the components
of the RAS, including the receptors, have been found in brain tissue,
indicating a role as a hormone or neuromodulator in the central nervous
system. Ang II exerts its principal known actions at the AT1 receptor.
Its functions related to AT2 receptors are controversial and associated
with AT1 opposite effects, although there is evidence showing crosstalk
between both receptors. The metabolism of Ang II generates
other active peptides, such as Angiotensin 1?7 and Angiotensin IV,
which will not be discussed. Neurobiological research has explained
many of the different neuroendocrine and behavioral responses to
stressors. Stress is a complex phenomenon in response to physical,
environmental, or psychological stimulus. Stress triggers important
adaptive functions improving health and survival. Meanwhile,
excessive stress can be deleterious, therefore, individuals unable to
cope with stress are highly vulnerable to a variety of diseases. Stress
is a major contributor of cardiovascular disorders and psychiatric
illness such as anxiety and depression. Many studies have confirmed
that stress also increases the vulnerability to drug abuse.
The role of Ang II at the periphery and in the central nervous system
is vast and complex. For this reason, in this chapter we will focus
on the role of brain RAS in stress responses and related pathologies
from many other important aspects of Ang II research.
