BREGONZIO DIAZ CLAUDIA
Capítulos de libros
Título:
Brain Renin-Angiotensin System: A Novel Therapeutic Target for Psychostimulant and Alcohol Related Disorders?
Autor/es:
PAZ MC; MARCHESE NA; BREGONZIO C; BAIARDI, G; GARGIULO, PA
Libro:
Psychiatric and Neuroscience update. Bridging the divide
Editorial:
Springer
Referencias:
Año: 2015; p. 89 - 99
Resumen:
The renin angiotensin system (RAS) is involved not only in the
regulation of blood pressure and fluid homeostasis, but also in the
modulation of multiple additional functions in the brain. In this
sense, it was found to be involved in many neuroadaptive responses
induced by drugs such as cocaine, amphetamines, alcohol, as well
as others.
It is known that the dopaminergic neurotransmission in the nucleus
accumbens and caudate-putamen plays a critical role in the
rewarding effects of psychostimulant drugs and alcohol. The main
and more studied actions of RAS are mediated by the neuropeptide
Angiotensin II (Ang II) that belongs to the group of peptides known
to stimulate dopamine release.
There is growing evidence showing the key role of RAS in the
development of neuroadaptive changes related to behavioral
sensitization induced by natural reinforcers and drugs known to be
abused. Recently, we found evidence involving the AT1 receptors
in the neuroadaptive changes induced by amphetamine. Moreover,
others found evidence that Ang II AT1 receptors are strongly involved
in ethanol intake in rodents.
Our goal is to present and discuss the evidence supporting an
important role of brain RAS in neuroadaptive responses induced by
two of the most abused drugs: amphetamine and alcohol, proposing
this system as a potential therapeutic target in the treatment of
disorders related to these drugs of choice for abuse.
regulation of blood pressure and fluid homeostasis, but also in the
modulation of multiple additional functions in the brain. In this
sense, it was found to be involved in many neuroadaptive responses
induced by drugs such as cocaine, amphetamines, alcohol, as well
as others.
It is known that the dopaminergic neurotransmission in the nucleus
accumbens and caudate-putamen plays a critical role in the
rewarding effects of psychostimulant drugs and alcohol. The main
and more studied actions of RAS are mediated by the neuropeptide
Angiotensin II (Ang II) that belongs to the group of peptides known
to stimulate dopamine release.
There is growing evidence showing the key role of RAS in the
development of neuroadaptive changes related to behavioral
sensitization induced by natural reinforcers and drugs known to be
abused. Recently, we found evidence involving the AT1 receptors
in the neuroadaptive changes induced by amphetamine. Moreover,
others found evidence that Ang II AT1 receptors are strongly involved
in ethanol intake in rodents.
Our goal is to present and discuss the evidence supporting an
important role of brain RAS in neuroadaptive responses induced by
two of the most abused drugs: amphetamine and alcohol, proposing
this system as a potential therapeutic target in the treatment of
disorders related to these drugs of choice for abuse.
