MASINI ANA MARIA DE LAS MERCEDES
Artículos
Título:
Dissociation of Thyrotropin-Dependent Enzyme Activities, Reduced Iodide Transport and Preserved Iodide Organification in Non-functioning Thyroid Adenoma and Multinodular Goiter
Autor/es:
MASINI-REPISO ANA M, CABANILLAS ANA M, BONATERRA MÓNICA , COLEONI ALDO H
Revista:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
Editorial:
The Endocrine Society
Referencias:
Lugar: Bethesda, MD, U.S.A; Año: 1994 vol. 79 p. 39 - 39
Resumen:
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Several biochemical and functional modifications demonstrated in goitrous tissues could reflect the effect of goitrogenic factors. Growth-enhancing agents, including TSH itself, have been involved in goitrogenesis. To study comparatively the variation patterns of some TSH-dependent enzymes within single goitrous tissues, we measured the activities of peroxidase (TPO), NADPH-cytochrome-c (cyt-c) reductase, and monoamine oxidase (MAO) in tissues from cold follicular adenoma (CA) and multinodular goiter (MG). Iodide transport and organification were also evaluated. Perinodular and necropsy tissues were used as controls. The mean TPO activity measured by guaiacol as well as triiodide assays was significantly increased in MG, whereas a nonsignificant increment was observed CA. NADPH-cyt-c reductase and MAO were markedly increased in the two types of pathological tissues. The individual activities of the three enzymes showed dissimilar modifications within single samples