Impact of contextual cues in the expression of the memory associated with diazepam withdrawal: involvement of hippocampal PKMf in vivo, and Arc expression and LTP in vitro

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2012 vol. 36 p. 3113 - 3113

ippocampal synaptic plasticity has been related to learning and adaptive processes developed during chronic drug administration, suggesting the existence of a common neurobiological mechanism mediating drug addiction and memory. Moreover, Protein Kinase M Zeta (PKMζ) is critical for the maintenance of hippocampal long-term potentiation (LTP) and spatial conditioned long-term memories. Also, a link between activity-regulated cytoskeletal-associated protein (Arc), PKMζ and LTP has been proposed. Our previous results demonstrated that re-exposure to the withdrawal environment was able to evoke the memory acquired when the diazepam withdrawal signs were experienced. In the present work we evaluated if the memory associated to diazepam withdrawal could be affected by changes in the contextual cues presented during withdrawal and by intrahippocampal administration of a PKMζ inhibitor. We found that the context was relevant for the expression of withdrawal sings sin