Genetic Analysis of a Novel Human Adenovirus with a Serologically Unique Hexon and a Recombinant Fiber Gene

LIU EB; LEONARDO FERREYRA; STEPHEN L. FISCHER; JORGE V. PAVAN; SILVIA V. NATES; NOLAN RYAN HUDSON; DAMARIS TIRADO; DAVID W. DYER; JAMES CHODOSH; DONALD SETO; MORRIS S. JONES

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco, CA; Año: 2011 vol. 6 p. 2449 - 2449

n February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea. To characterize this apparently novel pathogen of potential public health significance, the complete genome of this adenovirus was sequenced to elucidate its origin. Bioinformatic and phylogenetic analyses of this genome demonstrate that this virus, heretofore referred to as HAdV-D58, contains a novel hexon gene as well as a recombinant fiber gene. In addition, serological analysis demonstrated that HAdV-D58 has a different neutralization profile than all previously characterized HAdVs. Bootscan analysis of the HAdV-D58 fiber gene strongly suggests one recombination event.