Resumen:
h4>BACKGROUND:
The immunogenicity of inactivated poliovirus vaccine
(IPV) in developing countries is not well documented. This study
compared the immune response to IPV with that to oral poliovirus vaccine (OPV) in Guatemalan infants.
METHODS:
This was an open-label, randomized comparison of IPV only, OPV only, or IPV followed by OPV in Guatemalan
public health clinics. Serum samples were tested for neutralizing
antibodies, and stool samples were tested for Sabin strain polioviruses.
RESULTS:
Seropositivity rates 2 months after 2 doses of IPV were 98%-100% for polio
types 1, 2, and 3 and were 97.1%, 99.3%, and 92.1% fo