Randomized trial of inactivated and live polio vaccine schedules in Guatemalan infants.

EDWIN J. ASTURIAS; ERICA DUEGER; SAAD B. OMER; ARTURO MELVILLE; SILVIA V. NATES; MAJID LAASSRI; KONSTANTIN CHUMAKOV; NEAL A. HALSEY

UNIV CHICAGO PRESS

Año: 2007 vol. 196 p. 692 - 692

h4>BACKGROUND: The immunogenicity of inactivated poliovirus vaccine (IPV) in developing countries is not well documented. This study compared the immune response to IPV with that to oral poliovirus vaccine (OPV) in Guatemalan infants. METHODS: This was an open-label, randomized comparison of IPV only, OPV only, or IPV followed by OPV in Guatemalan public health clinics. Serum samples were tested for neutralizing antibodies, and stool samples were tested for Sabin strain polioviruses. RESULTS: Seropositivity rates 2 months after 2 doses of IPV were 98%-100% for polio types 1, 2, and 3 and were 97.1%, 99.3%, and 92.1% fo