Transdermal Delivery of Probenecid: the Effects of Vehicles

LUCÍA LHEZ; DANIEL A. ALLEMANDI; SANTIAGO D. PALMA; NORA B. PAPPANO; NORA B.DEBATTISTA

COLEGIO FARMACEUTICOS PROVINCIA DE BUENOS AIRES

Año: 2010 vol. 29 p. 602 - 602

b> Vehicles and enhancers effect on in vitro probenecid permeation through dermatomed abdominal pig skin was investigated. The permeability of different probenecid percentages dispersed in vehicles as vaseline, carbopol/ethanol/water and carbopol/propylene glycol was tested. The 1.3% L-menthol addition, as permeation enhancer, over probenecid/vaseline formulations showed the highest values for both, flux and permeation coefficient. Permeation experiments of the probenecid formulations in carbopol/ propylene glycol showed that the carbopol/probenecid concentration relation is the most important issue to be considered. Comp