Resumen:
his study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly
by gastrointestinal endocrine cells and released during periods of negative energy balance, in
two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the
olfactory bulbectomy (OB), an established animal model of depression. The reduction in the immobility
time in the TST was the parameter used to assess antidepressant-like effect of Ghr. The depressive-like
behavior in olfactory bulbectomized mice was inferred through the increase in the immobility time in
the TST and the hyperlocomotor activity in the open-field test. Ghr produced antidepressant-like effect
in TST (0.3 nmol/l, i.c.v.), and reversed OB-induced depressive-like behavior. In conclusion, these results
provide clear evidence that an acute administration of ghrelin produce antidepressant-like effect in the
TST and OB.