Comparative analysis of the effects of ghrelin and un-acylated ghrelin upon luteinizing hormone secretion in male rats.

MARTINI AC; FERNÁNDEZ-FERNÁNDEZ R; TOVAR S; NAVARRO VM; VIGO E; VASQUEZ MJ; DAVIES JS; THOMPSON NM; AGUILAR E; PINILLA L; WELLS T; DIEGUEZ C; TENA-SEMPERE M

ENDOCRINE SOC

Año: 2006 vol. 147 p. 2374 - 2374

p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: justify">Ghrelin, the endogenous ligando of GH secretagogue receptor type 1ª, has emerged as pleiotropic modulator of diverese biological functions, including energy homeostasis and, recently, reproduction. Although inhibitory actions of ghrelin on LH secretion and puberty onset have been reproted previously, the recptor mechanism mediating these actions, and the potencial gonadotropic effects of the unacylated isoform of ghrelin (UAG) remain nuclear. In this work, the effects of single and repeated administration of ghrelin or UAG on LH secretion were compared in pubertad and adult male rats. In addition, the effects of ghrelin were assessed in models of transient or persistent hypergonadotropism. Daily injection of gherlin or UAG throughout puberty similarly decreased LH levels and partially delayed balanopreputial separation. Likewise, chronic infusión of ghrelin or UAG to adult males resulted in significan