Molecular Organization and recognition properties of amphiphilic cyclodextrins

RITA H. DE ROSSI; O. FERNANDO SILVA; RAQUEL V. VICO; CARLOS J. GONZALEZ

IUPAC

Lugar: Londres; Año: 2009 vol. 81 p. 755 - 755

he continuing challenge of using cyclodextrins (CDs) for solubilization and drug targeting has led to the preparation of a wide variety of chemically modified derivatives in order to improve the properties of these host molecules. A possible approach for pharmaceutical applications would be to combine the recognition specificity of CDs with the transport properties of organized structures such as vesicles, liposomes, or micelles. Amphiphilic CDs can be admixed to phospholipid monolayers and to liposomes, and they can be dispersed into nanospheres showing promising properties for drug encapsulation. Monoacylated derivatives of β-CD, Mod-CD (Cn), were synthesized in our laboratory from the reaction of alkenyl succinic anhydride with β-CD. We found that the compound with 10 carbon atoms in the alkenyl chain, Mod-CD (C10), can be Incorporated into inverted micelles. We studied their properties in solution and at the air?water interface. In solution they have very low critical m