NATES SILVIA VIVIANA
Artículos
Título:
Long-lasting poliovirus-neutralizing antibodies among Argentinean population immunized with four or five oral polio vaccine doses 1 month to 19 years previously
Autor/es:
SILVIA V. NATES; LAURA C. MARTÍNEZ; PATRICIA A. BARRIL; LEONARDO FERREYRA; MIGUEL O. GIORDANO; GISELA MASACHESSI; MARÍA B. ISA
Editorial:
MARY ANN LIEBERT INC
Referencias:
Año: 2007 vol. 20 p. 3 - 3
Resumen:
he persistence of poliovirus-neutralizing antibodies was investigated in 297 individuals residing in Argentina who had completed the vaccination cycle with four or five oral polio vaccine (OPV) doses 1 mo to 19 yr before this study. Seropositivity for the three polio types in individuals who had received four OPV doses remained high and stable, showing rates not less than 94.6, 98.2, and 91.1% for types 1, 2, and 3, respectively, for a period of at least 6 yr. Almost identical rates were found in children who completed a vaccination schedule of five OPV doses 1 to 2 yr earlier. However, humoral immunity to poliovirus types 3 and 1 declined significantly 9 and 17 yr, respectively, after the booster dose had been administered; in contrast, type 2 immunity remained fairly stable during the 19-yr study period. Overall, geometric mean titer values for poliovirus types 1 and 2 were higher than those for poliovirus type 3. This is likely a result of low initial poliovirus type 3 antibody tit