NATES SILVIA VIVIANA
Artículos
Título:
Rotavirus VP7-gene selection during coinfections in CaCo-2 cells.
Autor/es:
PATRICIA A. BARRIL; MIGUEL O. GIORDANO; GISELA MASACHESSI; MARÍA B. ISA; ALEJANDRO CASTELLO; GRACIELA GLIKMANN; SILVIA V. NATES
Editorial:
ELSEVIER SCIENCE BV
Referencias:
Año: 2009 vol. 9 p. 210 - 210
Resumen:
previous rotavirus epidemiological survey in Córdoba, Argentina, revealed an unusually high frequency of mixed G-type infections (41.5%). The genotype distribution of those mixed infections showed that the most prevalent G-type combinations were G1+G4 (65.0%), G1+G2 (12.5%), G2+G4 (3.1%) and G1+G9 (2.5%). In the present study we analyzed the competitive growth in CaCo-2 cell cultures of strains from the most frequent rotavirus G-type coinfections in order to explain some aspect of the dynamic of G-type replacement along the time. Our results indicated that G1-type was preferentially selected compared with G2 and G9-genotypes, meanwhile, G1-G4 coinfections showed an efficient co-amplification of both types. Interestingly, this mirrored the high detection rates of both genotypes