Artículos
Título:
Silent Dissemination of HTLV-1 in an endemic area of Argentina. Epidemiological and molecular evidence of intrafamilial transmission.
Autor/es:
MARÍA CELIA FRUTOS; RENE GASTALDELLO; MARCOS BALANGERO; CARLOS REMONDEGUI; SEBASTIÁN BLANCO; KOKO OTSUKI; ANA CAROLINA PAULO VICENTE; DAVID ELÍAS; ARNALDO MANGEAUD; ; SILVIA NATES; ; SANDRA GALLEGO
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2017 vol. 12 p. 174920 - 174920
Resumen:
ackground: Molecular and epidemiological studies of the transmission routes and risk factors for infection by HTLV-1 are extremely important in order to implement control measures, especially because of the high prevalence of HTLV-1 in several regions of the world. San Salvador de Jujuy, Northwest of Argentina, is a highly endemic area for HTLV-1 and foci of tropical spastic paraparesis/HTLV-1-associated myelopathy.Objective: To gain further insight into the role of intrafamilial transmission of HTLV-1 in a highly endemic region in Argentina.Method: Cross-sectional study in Northwest Argentina. Epidemiological data and blood samples were collected from 28 HTLV-1 infected subjects (index cases) and 92 close relatives/cohabitants. HTLV-1 infection was diagnosed by detection of antibodies and proviral DNA. The LTR region was sequenced and analyzed for genetic distances (VESPA software), in addition to determination and identification of polymorphisms to define HTLV-1 family signatures.Re