Maternal and postnatal high-fat diets with high omega6 omega3 ratios affect the reproductive performance of male offspring in the mouse

BIANCONI S; STUTZ G; SOLIS MR; MARTINI A.C.; VINCENTI LM; PONZIO M.F.; LUQUE E; AVENDANO C; QUIROGA P; SANTILLAN ME

REPRODUCTION FERTILITY AND DEVELOPMENT

CSIRO PUBLISHING

Lugar: Collingwood; Año: 2018

1031-3613

div>High-fat diets (HFDs) are an acknowledged risk factor for male subfertility, but the underlying mechanisms remain unclear. In the present study we compared the effects of two HFDs with different ù6:ù3 ratios, one enriched with soy oil (SOD; ù6:ù3=9.62) and another enriched with sunflower oil (SFOD; ù6:ù3=51.55), with those of a commercial diet (CD; ù6:ù3=19.87), supplied from pregnancy to adulthood, on morphometric parameters and reproductive performance in adult male mice (recommended ù6:ù3 for rodents=1-6). Bodyweight was significantly higher in the SFOD than CD group, and relative testicular weight was significantly lower in the SFOD than the other two groups. SFOD altered sperm performance: it reduced sperm viability (mean±s.e.m.; 76.00±1.35% vs 82.50±1.45% and 80.63±1.00% in the SFOD vs CD and SOD groups respectively; P<0.05) and increased the percentage of immature spermatozoa (71.88±7.17% vs 51.38±5.87% and 48.00±5.72% in the SFOD vs CD and SOD groups respectively; P&