BALZARINI MONICA GRACIELA
Artículos
Título:
Molecular Kinetics Modeling in Hemodialysis: On-Line Molecular MOnitoring and Spectral Analysis
Autor/es:
FERNADEZ E; PERAZZO C; VALTUILLE R; WILLSAHAW P; BALZARINI M
Revista:
ASAIO JOURNAL
Editorial:
ASAIO
Referencias:
Lugar: Lexington, NY; Año: 2007 vol. 53 p. 582 - 582
ISSN:
1058-2916
Resumen:
b> The knowledge of the underlying molecular kinetics is a key point for the development of a dialysis treatment as well as for patient monitoring. In this work, we propose a kinetic inference method that is general enough to be used on different molecular types measured in the spent dialysate. It estimates the number and significance of the compartments involved in the overall process of dialysis by means of a spectral deconvolution technique, characterizing thereforethe kinetic behavior of the patient. The method was applied to 52 patients to reveal the underlying kinetics from dialysate time-concentration profiles of urea, which has a well-known molecular kinetic. Three types of behaviors were found: onecompartmental (exponential decay Tau 180