Comparación de ordenaciones de muestras a nivel de secuencias de aminoácidos, nucleótidos y marcadores RFLP

BRUNO CECILIA; GIMÉNEZ PECCI MARÍA DE LA PAZ; ARROYO ALEJANDRA; BALZARINI MÓNICA

Sociedad Argentina de Genética

Lugar: Buenos Aires; Año: 2007 vol. 1 p. 39 - 39

p class="MsoNormal" style="MARGIN: 6pt 0cm">Between sample distances obtained from nucleotide and amino acid sequences as well as from DNA marker data are frequent in Molecular Biology. The Multidimensional Scaling (MDS) is an statistical technique that allows to explore the underlying relationships among samples via graphical representation of their distance matrix. Reconstructing a matrix so that it can be visualized in a plane is an optimization problem. With m p-dimensional samples, the MDS uses a distance matrix Dm×m as input, and obtains coordinates to order the m samples in a reduced space such as a plane. In this paper, we ordered four viral cDNA samples through MDS applied on matrices of different nature: Jones-Taylor-Thornton distance between protein sequences, Felsenstein84 distance between nucleotide