A Simple Thermodynamic Test To Discriminate between Two-State and Downhill Folding

FABIANA Y. OLIVA; VICTOR MUÑOZ

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

American Chemical Society

Año: 2004 vol. 126 p. 8596 - 8596

0002-7863

font face="Times New Roman" size="1"> One of the main targets in designing protein structures de novo has been to achieve proteins that fold in a two-state manner.1-3 The implicit assumption is that single domain natural proteins are intrinsically two-state systems.4 Such a premise might require reevaluation after the recent discovery of downhill protein folding.5, 4 Such a premise might require reevaluation after the recent discovery of reevaluation after the recent d