Adsorption of human serum albumin (HSA) onto colloidal TiO2 particles, Part I

FABIANA Y. OLIVA; LUCÍA B. AVALLE; OSVALDO R. CÁMARA; CARLOS P. DE PAULI

JOURNAL OF COLLOID AND INTERFACE SCIENCE

Elsevier

Año: 2003 vol. 261 p. 299 - 299

0021-9797

font face="Times New Roman" size="1"> The adsorption of human serum albumin (HSA) onto colloidal TiO2 (P25 Degussa) particles was studied in NaCl electrolyte at different solution pH and ionic strength. The HSA–TiO2 interactions were studied using adsorption isotherms and the electrokinetic properties of HSA-covered TiO2 particles were monitored by electrophoretic mobility measurements. The adsorption behavior shows a remarkable dependence of the maximum coverage degree on pH and was almost independent of the ionic strength. Other characteristic features such as maximum adsorption values at the protein isoelectric point (IEP